Nukes games: yep fair enough this should be disabled as it's obviously crucial to avoid self-nuking (doh! didn't think of that as I rarely play them).
Escalating games: If you had 5 cards with several ways of playing them then this could suggest a set to play, or list each possible way of cashing them in - or like Nukes, just don't have it for those game types.
I'm guessing that whilst some players on here love the two game types above and play nothing else, they'd be the exception. Without a shred of data to back it up

I'd suggest that 80-90% of games played on here with spoils would be standard? Lots anyway

and this is where it helps out.